These changes in epithelial and mesenchymal cell marker expression lead to a reduction in adhesion between the transitioning cell and adjacent epithelial cells and an increase in the secretion of enzymes that degrade the extracellular matrix. EMT is characterized by a loss of epithelial cell markers, such as cytokeratins and E-cadherin, followed by an upregulation in the expression of mesenchymal cell markers, such as N-cadherin, vimentin, and fibronectin. Jump to: E-cadherin | N-cadherin | Vimentin | SNAIL What is epithelial-mesenchymal transition? Epithelial-mesenchymal transition (EMT) is a critical process in cancer cell metastasis, during which epithelial cells acquire mesenchymal characteristics, including enhanced cell motility and migration. To help you quickly select the right tools to study EMT, we've compiled the most common EMT markers and recommended reliable antibodies for these markers.
